Figure 3

OPEN and CLOSED state of SPIKE SARS-COV-2: relationship with some integrin binding. A biological molecular approach to better understand the coagulant effect

Luisetto M*, Khaled Edbey, Mashori GR, Yesvi AR and Latyschev OY

Published: 02 July, 2021 | Volume 5 - Issue 1 | Pages: 049-056

abb-aid1028-g003

Figure 3:

3: (A) Schematic of SARS-CoV-2 spike- protein primary- structure. Different domains are shown by different colors. SS, single- sequence; NTD, N-terminal domain; RBD, receptor-binding domain; SD1, subdomain 1; SD2, sub-domain 2; S1/S2, S1/S2 protease cleavage- site; S2’, S2’ protease cleavage site; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector -domain; HR2, heptad repeat 2; TM, transmembrane- domain; CT, cytoplasmic tail. The protease cleavage site is indicated by arrows. (B) Cryo-EM structure of the SARS-CoV-2 spike protein. The closed- state (PDB: 6VXX) of the SARS-CoV-2 S glycoprotein (left) the open state (PDB: 6VYB) of the SARS-CoV-2 S glycoprotein (right).

Read Full Article HTML DOI: 10.29328/journal.abb.1001028 Cite this Article Read Full Article PDF

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