Abstract

Review Article

OPEN and CLOSED state of SPIKE SARS-COV-2: relationship with some integrin binding. A biological molecular approach to better understand the coagulant effect

Luisetto M*, Khaled Edbey, Mashori GR, Yesvi AR and Latyschev OY

Published: 02 July, 2021 | Volume 5 - Issue 1 | Pages: 049-056

Related the physio-pathological process of COVID-19 disease it is interesting to focus to the aspect.

Played by interaction of Sars-Cov-2 protein with integrins of human epithelial pulmonary cell.

A bio molecular approach help in to deeply verify the involved factors and the results of this Activation RGD mediated.

Of Great interest also the relationship with some vaccine strategy followed by the various pharmaceutical industry.

The results of this work will be useful to think modification in some vaccine increasing the global safety and related some rare ADR.

Read Full Article HTML DOI: 10.29328/journal.abb.1001028 Cite this Article Read Full Article PDF

Keywords:

SPIKE; RGD; Integrin; Coagulation; Quantitative effect; Molecular approach

References

  1. Mei-Yue W, Zhao R, Li-Juan G, Xue-Fei G, De-Ping W, et al. SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development. Front Cell Infect Microbiol. 2020; 10: 587269. PubMed: https://pubmed.ncbi.nlm.nih.gov/33324574/
  2. Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, et al. A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment. Front Mol Biosci. 2020; 7: 186. PubMed: https://pubmed.ncbi.nlm.nih.gov/32850973/
  3. Luan J, Lu Y, Gao S, Zhang L. A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2. 2020; 81: 318-356. PubMed: https://pubmed.ncbi.nlm.nih.gov/32283163/
  4. Calver J, Joseph C, John AE, Organ L, Fainberg H, et al. Understanding lung infection: back to basics. S31 The novel coronavirus SARS-CoV-2 binds RGD integrins and upregulates avb3 integrins in Covid-19 infected lungs. Thorax BMJ. 2021; 76: A22-A23.
  5. Zhang S, Liu Y, Wang X, Yang L, Li H, et al. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol. 2020; 13: 120. PubMed: https://pubmed.ncbi.nlm.nih.gov/32887634/
  6. Allegra A, Innao V, Allegra AG, Musolino C. Coagulopathy and thromboembolic events in patients with SARS-CoV-2 infection: pathogenesis and management strategies. Ann Hematol. 2020; 99: 1953-1965. PubMed: https://pubmed.ncbi.nlm.nih.gov/32671455/
  7. Liu Y, Yang Y, Zhang C, Huang F, Wang F, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020; 63: 364-374. PubMed: https://pubmed.ncbi.nlm.nih.gov/32048163/
  8. Smadja DM, Qun-Ying Y, Chocron R, Sanchez O, Louet AL. Vaccination against COVID-19: insight from arterial and venous thrombosis occurrence using data from VigiBase. Eur Respir J. 2021; 2100956. PubMed: https://pubmed.ncbi.nlm.nih.gov/33863748/
  9. Loo KY, Letchumanan V, Ser HL, Teoh SL, Law JWF, et al. COVID-19: Insights into Potential Vaccines. Microorganisms. 2021; 9: 605. PubMed: https://pubmed.ncbi.nlm.nih.gov/33804162/
  10. Grobbelaar LM, Venter C, Vlok M, Ngoepe M, Laubsche GJ, et al. SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19. 202

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